Publications
A Chicken Tapasin ortholog can chaperone empty HLA-B∗37:01 molecules independent of other peptide-loading components.
Georgia F. Papadaki, Claire H. Woodward, Michael C. Young, Trenton J. Winters, George M. Burslem, and Nikolaos G. Sgourakis
Journal of Biological Chemistry October 2023
HLA3DB: comprehensive annotation of peptide/HLA complexes enables blind structure prediction of T cell epitopes
Sagar Gupta, Santrupti Nerli, Sreeja Kutti Kandy, Glenn L. Mersky & Nikolaos G. Sgourakis
Nature Communications 10 October 2023
Bioinspired 3D microprinted cell scaffolds: integration of graph theory to recapitulate complex network wiring in lymph nodes.
Matthew H. W. Chin, Barry Reid, Veronika Lachina, Sophie E. Acton, Marc-Olivier Coppens
Biotechnology Journal 20 November 2023
Structural principles of peptide-centric Chimeric Antigen Receptor recognition guide therapeutic expansion
Yi Sun, Tyler J. Florio, Sagar Gupta, Michael C. Young, Quinlen F. Marshall, Samuel E. Garfinkle, Georgia F. Papadaki, Hau V. Truong, Emily Mycek, Peiyao Li, Alvin Farrel, Nicole L. Church, Shereen Jabar, Matthew D. Beasley, Ben R. Kiefel, Mark Yarmarkovich, Leena Mallik, John M. Maris, Nikolaos G. Sgourakis
Science Immunology 1 December 2023
Conformational plasticity of RAS Q61 family of neoepitopes results in distinct features for targeted recognition
Andrew C. McShan, David Flores-Solis, Yi Sun, Samuel E. Garfinkle, Jugmohit S. Toor, Michael C. Young & Nikolaos G. Sgourakis
Nature Communications 1 December 2023
Directed evolution of genetically encoded LYTACs for cell-mediated delivery
Jonathan Lee Yang, Sean A. Yamada-Hunter, Louai Labanieh, Elena Sotillo, Joleen S. Cheah, David S. Roberts, Crystal L. Mackall, Carolyn R. Bertozzi, and Alice Y. Ting
PNAS 22 March 2024
Two conjectures on 3D Voronoi structures: a toolkit with biomedical case studies
Lucy Todd, Matthew H. W. Chin, Marc-Olivier Coppens
Molecular Systems Design and Engineering 24 May 2024
A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma
Amber K. Weiner, Alexander B. Radaoui, Matthew Tsang, Daniel Martinez, Simone Sidoli, Karina L. Conkrite, Alberto Delaidelli, Apexa Modi, Jo Lynne Rokita, Khushbu Patel, Maria V. Lane, Bo Zhang, ….et al, John M. Maris, Sharon J. Diskin
Cancer Cell 24 October 2024
MR-1 restricted recognition of cancer via a semi-invariant TCRa chain
Garry Dolton, Hannah Thomas, Li Rong Tan, Cristina Rius, Stephanie Doetsch, Giulia-Andreea Ionescu, Lucia F. Cardo, Michael D. Crowther, Enas Behiry, Théo Morin, Marine Caillaud, Devinder Srai, Lucia Parolini, Md Samiul Hasan, Anna Fuller, Katie Topley, Aaron Wall, Jade R. Hopkins, Nader Omidvar, Caroline Alvares, Joanna Zabkiewicz, John Frater, Barbara Szomolay and Andrew K. Sewell
Journal of Clinical Investigation 2 January 2025
CryoEM structure of an MHC-I/TAPBPR peptide-bound intermediate reveals the mechanism of antigen proofreading.
Yi Sun, Ruth A. Pumroy, Leena Mallik, Apala Chaudhuri, Chloe Wang, Daniel Hwang, Julia N. Danon, Kimia Dasteh Goli, Vera Y. Moiseenkova-Bell, and Nikolaos G. Sgourakis
PNAS 9 January 2025
ImmunoTar-integrative prioritization of cell surface targets for cancer immunotherapy
Rawan Shraim, Brian Mooney, Karina L. Conkrite, Amber K. Weiner, Gregg B. Morin, Poul H. Sorensen, John M. Maris, Sharon J. Diskin, Ahmet Sacan
Bioinformatics 11 February 2025
LION Data: A roaring transformation in data visualisation
Lucy Todd, Arthur Fordham, Ben Deacon, Marc-Olivier Coppens
Computers & Chemical Engineering 8 May 2025
Solution mapping of MHC-I:TCR interactions using a minimalistic protein system
Claire H. Woodward, Apala Chaudhuri, Xiaojing Chen, William White, K. Christopher Garcia, David Baker and Nikolaos G. Sgourakis
PNAS 9 June 2025
A structure-guided approach to predict MHC-I restriction of T cell receptors for public antigens
Sagar Gupta and Nikolaos G. Sgourakis
Structure 4 September 2025
Engineering T cells with a membrane-tethered version of SLP-76 overcomes antigen-low resistance to CAR T cell therapy
Maria Caterina Rotiroti, Aidan M. Tousley, Hoyin Chu, Marco Herrera-Barrera, Antigoni Manousopoulou, Won-Ju Kim, Yajie Yin, Malcolm Holterhus, Lea Wenting Rysavy, Guillermo Nicolas Dalton, Gernot Kaber, Korbinian N. Kropp, Christopher A. Klebanoff, Ansuman T. Satpathy, Leo D. Wang, Caleb A. Lareau, Robbie G. Majzner
Nature Cancer 23 October 2025
Atomically accurate de novo design of antibodies with RFdiffusion
Nathaniel R. Bennett, Joseph L. Watson, Robert J. Ragotte, Andrew J. Borst, DéJenaé L. See, Connor Weidle, Riti Biswas, Yutong Yu, Ellen L. Shrock, Russell Ault, Philip J. Y. Leung, Buwei Huang, Inna Goreshnik, John Tam, Kenneth D. Carr, Benedikt Singer, Cameron Criswell, Basile I. M. Wicky, Dionne Vafeados, Mariana Garcia Sanchez, Ho Min Kim, Susana Vázquez Torres, Sidney Chan, Shirley M. Sun, Timothy T. Spear, Yi Sun, Keelan O’Reilly, John M. Maris, Nikolaos G. Sgourakis, Roman A. Melnyk, Chang C. Liu & David Baker
Nature 5 November 2025
HLA-Shuttle: A system for enhancing antigen presentation in immunologically cold tumors
Daniel Hwang, Molly C. Erdman, Santosh Adhikari, Kaya Epstein, Peiyao Li, Chloe Wang, Ram Pantula, Shirley M. Sun, Hossein Fazelinia, Lynn A. Spruce, Tim Fugmann, Trendelina Rrustemi, Alvin Farrel, Muzamil Y. Want, Mustafa Mir, John M. Maris, Nikolaos G. Sgourakis
Science Advances 1 January 2026
Design of solubly expressed miniaturized SMART MHCs
William L White, Hua Bai, Chan Jhong Kim, Kevin M Jude, Renhua Sun, Laura Guerrero, Xiao Han, Xiaojing Chen, Apala Chaudhuri, Julia E Bonzanini, Yi Sun, Amarachi E Onwuka, Nan Wang, Chunyu Wang, Per-Åke Nygren, Xinting Li, Inna Goreshnik, Aza Allen, Paul M Levine, Hao Yuan Kueh, Michael C Jewett, Nikolaos G Sgourakis, Adnane Achour, K Christopher Garcia, David Baker
PNAS 6 January 2026
Engineering high-fidelity tapasin variants to enhance MHC-I antigen presentation
Molly C Erdman, Kaya Epstein, Daniel Hwang, Radia MM Khan, Shirley M Sun, Nikolaos G Sgourakis
J Biol Chem 21 March 2026
Microfluidic perspectives on chimeric antigen receptor T-cell migration in solid tumours: highlighting physical confinement as a key barrier
Valeria Gonzalez Abrego, Matthew Chin, and Marc-Olivier Coppens
Mol. Syst. Des. Eng. 15 May 2026
Ready-to-load MHC-I Nanoparticles for High-throughput T cell Screening Studies
Hoang-Anh Phan, Daniel Hwang, Michael Young, Shirley Sun, Dimitri Monos, Nikolaos G Sgourakis
Science Advances 12 June 2026
Multi-antigen-targeting T cells in pediatric central nervous system tumors: a phase 1 trial
Stephanie Gomez, Rachel A DiCioccio, Ashley E Geiger, Melanie L Grant, Emily Reynolds, Anushree Datar, Chase D McCann, Jay Tanna, Divyesh Kukadiya, Fahmida Hoq, Anqing Zhang, Patrick J Hanley, Jennifer L Webb, Lindsay B Kilburn, Brian R Rood, Adriana Fonseca, Holly J Meany, L. Gilbert Vézina, Roger J Packer, Conrad Russell Y Cruz, Catherine M Bollard, Eugene I Hwang
Nature Medicine 30 June 2026
Odon: An ultra-fast viewer for spatial proteomics
Alex Coulton and Nicky McGranahan
Bioinformatics 11 July 2026
High-Risk Rhabdomyosarcomas Feature a Convergent Cell State
Holly J. Whitfield, Nathaniel D. Anderson, Christina Burke, Marian J. Groot Koerkamp, Conor Parks, Toochi Ogbonnah, Yvette Wood, Alice Piapi, Emilia Robertson, Eleanor Watt, Abigail White, et al, Karin Straathof, and Sam Behjati
Cancer Research 14 July 2026
A Patient-Derived Screen Identifies HDAC Inhibitors as Enhancers of Phagocytosis and Potent Immunotherapy Partners
Mona Khalaj, Andrew T Burden, Madison L Gutierrez, Sophia C Hoonsbeen, Parisa Nejad, Tal Raveh, Jacob S Young, Faranak Fattahi, Irving L Weissman
Cancer Immunol Res 14 July 2026
